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KMID : 0357919860200010060
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Korean Journal of Pathology
1986 Volume.20 No. 1 p.60 ~ p.70
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Primary Squamous Cell and Adenosquamous Carcinomas of the Stomach -Clinico-pathologic analysis of 6 cases-
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Abstract
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Squamous cell carcinomas and adenosquamous carcinomas are rarely originated from
the stomach, thus the limited and sporadic informations about their clinics-pathologic
characteristics as well as histogenesis have been elucidated.
Six crises of primary squamous cell carcinoma (3 cases) and adenosquamous
carcinoma(3 cases) in the stomach were examined during a period of 4 years from 1981
to 1984. After pertinent review of both clinical data and morphology through extended
histotopographic study performed on 4 cases, their clinicopathologic characteristics were
described.
Male to female sex ratio was 4 : 2 and average age was 58.6 years. Clinical
presentations or physical findings were not different from those of adenocarcinoma.
Tumor masses of all cases were located in the body or pyloric antrum. In all crises
except for the early gastric carcinoma, each tumor was larger than 8 cm in long axis,
and showed expansile and intraluminal endophytic growing tendencies with sharp
margin. Simple Borrmann's macroscopic classification was applicable to none of 6 cases
because of irregular ,and multicentric ulceration pattern and occasional submucosal
growth which were reminiscent of those in submucosal tumors such as malignant
lymphoma and leiomyosarcoma. Virtually four out of all six cases were diagnosed as
submucosal tumor at the time of radiological examination.
Microscopically three cases were composed of pure squamous cell carcinoma and
remaining three contained both adeno and squamous components.
Metastatic regional lymph nodes revealed only squamous element in case of pure
squamous cell carcinoma, while both components were identified in adenosquamous
carcinomas.
Surrounding non-tumorous mucosa exhibited moderate to severe degree of intestinal
metaplasia accompanied by multifocal mucin pool formation.
Growth pattern and surrounding mucosal changes as with older age prevalence of
these tumors might express the biological behavior of intestinal type of gastric
carcinoma.
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